ah receptor造句

• The physiological function of the AH receptor has been the subject of continuous research.
• These polycyclic hydrocarbons also activate the AH receptor, but less than TCDD and only temporarily.
• Excessive and persistent stimulation of AH receptor, however, leads to a multitude of adverse effects.
• In fact, knock-out animals with no AH receptor are prone to illness and developmental problems.
• Taken together, this implies the necessity of a basal degree of AH receptor activation to achieve normal physiological function.
• Mutagenic effects have been established for some lower chlorinated chemicals such as 3-chlorodibenzofuran, which is neither persistent nor an AH receptor agonist.
• One such ClPAH, 6-chlorochrysene, has been shown to have a high affinity for the Ah receptor and to be a potent AHH inducer.
• The endocrine disrupting activity of dioxins is thought to occur as a down-stream function of AH receptor activation, with thyroid status in particular being a sensitive marker of exposure.
• Furthermore, xenoestrogens expose fish to CYP1A inducers through inhibiting a putative labile protein and enhancing the Ah receptor, which has been linked to epizootics of cancer and the initiation of tumors.
• The AH receptor is phylogenetically highly conserved transcription factor with a history of at least 500 million years, and found in all vertebrates, and its ancient analogs are important regulatory proteins even in more primitive species.